Category — Breaking News and Research Reviews

Content courtesy Alan Fogel

Pelvic organ prolapse, difficult urination, frequency, urgency and overactive bladder – for some women, it’s all related.

(C) Lauri Romanzi 2010

Pelvic organ prolapse and overactive bladder. de Boer TA, et al. Neurourol Urodyn. 2010;29(1):30-9.

Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

Medical research comes in several forms. This particular study gathered all the research already published on the topic, pooling all the data in one big group for re-analysis. Called meta-analysis, studies that pool data from other studies advance medical science by reviewing smaller clinical trials to figure out if the findings have anything in common that might thereby be considered “true”.

courtesy womensvoicesforchange.org

Look at this picture – what a mess. There’s no way bladders caught in the clutches of severe pelvic organ prolapse can function properly. The urethra, a 2-3 inch straw-shaped tube that allows urine to pass out of the bladder, is often kinked or compressed by the prolapse. The muscles in the bladder wall, normally located above the urethra, are now below the urethra, forced to fight the mighty forces of gravity and the kinked or compressed urethra, in order to empty, and as a result, the emptying is often incomplete. So the bladder fills up more quickly, starting a whole cascade of symptoms, enough to make any bladder crazy.

Not emptying fully, the bladder fills more quickly. Result? Frequency. And a propensity to bladder infections from all that stagnant urine. You used to urinate a few times a day without much thought, but now bladder management is a part-time job. Urine flow is very slow, dribbling, and sometimes stop – and – start.  This condition is called bladder outlet obstruction.

Contracting extra-hard in this upside down position in order to bypass gravity and urethral obstruction from all that kinking or compression, the bladder starts to misfire, suddenly contracting without any warning of fullness, as if it can’t make up it’s mind. Result? Urgency, that horrible sensation of needing to get to the bathroom RIGHT NOW and wondering if you’re going to make it in time. Or not making it in time, literally peeing in your pants on your mad dash to the water closet (urge incontinence). This condition is called overactive bladder.

courtesy "Plumbing and Renovations"

The common findings in the studies included in this meta-analysis showed that any method of successfully managing the prolapse, be it pessary or surgery, allowed the bladder to return to normal function. Anything that un-kinks the urethra, re-positions the bladder so that it’s on top of, instead of underneath, the urethra, and repositions all the pelvic organs to their normal location will normalize bladder function in most cases. Why is this an important finding? Because it helps doctors understand that, in a woman with prolapse and bladder problems, just fixing the prolapse ought to fix the bladder problems, without overactive bladder medications or the need for constant antibiotics to fight all those urinary tract infections.

Here is a synopsis of the data (aka abstract) of this study:

Abstract

AIMS: In this review we try to shed light on the following questions: *How frequently are symptoms of overactive bladder (OAB) and is detrusor overactivity (DO) present in patients with pelvic organ prolapse (POP) and is there a difference from women without POP? *Does the presence of OAB symptoms depend on the prolapsed compartment and/or stage of the prolapse? *What is the possible pathophysiology of OAB in POP? *Do OAB symptoms and DO change after conservative or surgical treatment of POP? METHODS: We searched on Medline and Embase for relevant studies. We only included studies in which actual data about OAB symptoms were available. All data for prolapse surgery were without the results of concomitant stress urinary incontinence (SUI) surgery. RESULTS: Community- and hospital-based studies showed that the prevalence of OAB symptoms was greater in patients with POP than without POP. No evidence was found for a relationship between the compartment or stage of the prolapse and the presence of OAB symptoms. All treatments for POP (surgery, pessaries) resulted in an improvement in OAB symptoms. It is unclear what predicts whether OAB symptoms disappear or not. When there is concomitant DO and POP, following POP surgery DO disappear in a proportion of the patients. Bladder outlet obstruction is likely to be the most important mechanism by which POP induces OAB symptoms and DO signs. However, several other mechanisms might also play a role. CONCLUSIONS: There are strong indications that there is a causal relationship between OAB and POP

(c) Lauri Romanzi, 2010

As a relentless advocate for avoiding hysterectomy unless you will truly benefit from the surgical removal of your uterus, I am here to share information about the benefits of  hysterectomy when it’s done for all the right reasons.

My favorite “don’t need a hysterectomy” message is  about uterine resuspension for treatment of uterine prolapse, a condition that accounts for about 16% of benign hysterectomies in the States, being the third most common indication for hysterectomy after fibroids and dysfunctional bleeding. Since uterine resuspension fixes uterine prolapse just as well as hysterectomy-based repairs, there is no need to undergo hysterectomy for prolapse.

But what if you’re suffering with a condition for which hysterectomy truly can make a difference?

Is there any such thing as a Happy Hysterectomy?

The Female Pelvis

Fibroids, adenomyosis, dysfunctional bleeding and endometriosis are the biggest players in this “do I or don’t I” hysterectomy arena. Let me help you understand something most of you already intuitively know – one woman’s hysterectomy blessing is another woman’s hysterectomy nightmare. What turned your neighbor’s life into a happy healthy place might not work so well for you.

According to a  beautifully designed and implemented research project recently published in the bible of gynecologic research, ”Obstetrics and Gynecology”, whether you’ll celebrate or regret your hysterectomy depends on how much headache your uterine condition is causing in terms of pain, painful sex, heavy bleeding, pelvic pressure, and fatigue from the anemia caused by heavy bleeding, combined with how you feel about your uterus, and how you feel about hysterectomy.

With the right mix of severe, recalcitrant uterine problems in the setting of unsuccessful non-hysterectomy therapies, and a laissez-faire attitude toward the role of your uterus in your version of womanhood, a hysterectomy may turn out to be best thing you ever did. But when the clinical/personal mix leaves you feeling like less of a woman and wondering why you signed up to remove an organ that plays a crucial role in your feminine identity, you may well regret your hysterectomy.

Sometimes the best clinical research just makes a lot of sense.

The March 2010 issue debuted the Study of Pelvic Problems, Hysterectomy, and Intervention Alternatives (SOPHIA).  Taking 10 years to complete, this team of researchers from California’s Kaiser Permanente HealthCare System painstakingly kept track of over 1400 women with benign (non-cancerous) uterine and other pelvic problems as they decided to undergo hysterectomy, undergo alternatives to hysterectomy, or decide not to decide by foregoing treatment in favor of TIME, the unsung heroine of benign uterine problems. If you can hang in there until menopause starts, most likely your uterus will calm down and the symptoms will … just… slowly… stop.

At the beginning of the trial, women were asked how they felt about  the

“benefits of not having uterus”

• lack of menstruation,
• uselessness of uterus once childbearing complete,
• no more birth control concerns

the

“value of the uterus ”

• sexual function
• feeling complete as a woman

and

“hysterectomy concerns”

• feeling older
• violated
• sad about loss of fertility resulting from hysterectomy

Over the ensuing decade, these self-rated attitudes were compared to symptom impact on each woman’s overall quality of life and sexual function as she dealt with her gynecologic disorder.

Guess what they found? Among the women who chose hysterectomy, those who felt that the benefits of not having a uterus outweighed the value of having a uterus and hysterectomy concerns, or for whom the underlying condition had major impact on quality of life and sexual function (pain in daily life, uncontrollable bleeding, painful sex, constipation, irritable  bowel, overactive bladder, urinary incontinence and the like) and for whom non-hysterectomy therapies did not work who did not want to wait for natural menpause to but the brakes on the condition, reported that hysterectomy improved quality of life in a major and regret-free fashion,  including, when applicable, their sex lives.

Women for whom the underlying condition was not associated with severe impact on quality of life and sexuality, and who rated the value of having a uterus and hysterectomy concerns higher than benefits of not having a uterus were more likely to regret the hysterectomy.

Over the past 25 years many a gynecologic staple indication for hysterectomy now comes with non-hysterectomy options. Conditions include fibroids (extremely common benign smooth muscle tumors of the uterus that can make for heavy or irregular periods, pelvic pressure, colorectal and urinary difficulties, infertility and enlarged abdomen), adenomyosis (spongy super-thickening of the lining of the uterus that can cause heavy and irregular periods), and endometriosis (abnormal location of uterine lining tissue outside of the uterus itself where it does not belong, often implanting on the tubes, ovaries, intestines and other pelvic organs causing pelvic pain, scarring and infertility). These options include hormone suppression with birth control pills or hormone-containing IUD (intrauterine contraceptive device), endometrial ablation using controlled cautery of the lining of the uterus so that it doesn’t bleed very much, (http://www.nlm.nih.gov/medlineplus/ency/article/000903.htm), or shrinking fibroids using  uterine artery embolization, a radiologic procedure that threads a tube into the uterine artery through the groin, injecting embolic material that blocks bloodflow to the fibroids. (http://www.nlm.nih.gov/medlineplus/ency/article/007384.htm).

So now we’ve got choices, and they often work quite well. It used to be wait for menopause, take harsh hormones, (look up Danazol for endometriosis when you have a chance), clean out the uterus with a D&C, and if none of that worked, your options were restricted to toughing it out or hysterectomy.

Besides these new therapies, it is important to understand that not every condition needs treating. Mild endometriosis may never cause a problem short of a tendency to painful periods, or it can be as brutal as a cancer, socking onto every organ in the pelvis, ruining your fertility and making you feel like your belly’s on fire. Fibroids can be cute little nubbins scattered here and there with nary a clinical impact, or they can be gigantic super-ball-consistency uterine tumors the size of your head.  Dysfunctional bleedng tack a few extra days on to your period, or it can be a  hemorrhagic pad-soaking, anemia inducing tsunami that knocks the wind out of your life every month.

In the SOPHIA trial, of the 1400 women participating fully for the entire 10 years, only 207 (14.6%) chose hysterectomy- ”These women were more likely to report symptomatic fibroids and that they did not want to become pregnant” at the beginning of the study”. ” Women who reported higher levels of pelvic problem impact on sex or who had higher (mental stress) scores were more likely to choose hysterectomy as were women wtih higher scores on the “benefits of not having a uterus” scale and lower scores on teh ‘hsterectomy concerns” scale.  63.9% of the 207 women who chose hysterectomy were very satisfied with the results. but nearly 22% were only  somewhat satisfied, about 7% were ambivalent, with the remaining, about 8%, frankly dissatisfied.  The majority of women who used uterine artery embolization and endometrial ablation did not go on to hysterectomy, highlighting the growing role of these effective, uterine-preserving operations for conditions traditionally treated with hysterectomy.

The authors further state “Perhaps the most noteworthy are our findings regarding the significant role of women’s attitudes toward their uterus and hsyterectomy in their decision making regarding and satisfaction with this surgery.”, and “We cannot comment, however, on the extent to which these attitudes were elicited by or shared with physicians.”

Here’s the deal, if the condition is benign but truly ruining your life, and you really like your uterus, find a gynecologist who shares your perspective, and try the all appropriate non-hysterectomy therapies. For those of you who’ve already done everything BUT the hysterectomy, and the fibroids/bleeding/pain is DRIVING YOU NUTS, a hysterectomy just might make your life a lot better.

The Aging Ovary

HEADS UP: for most non-medical people, hysterectomy = remove the uterus and ovaries. The medical definition of hysterectomy, however, is removal of uterus only, ovaries LEFT IN PLACE.  Your ovaries make almost all of your sex hormones. And even if you’re menopausal, there may be some good  reasons to leave your ovaries right where they are until age 75 or so – see

http://www.ncbi.nlm.nih.gov/pubmed/20226402,

http://www.ncbi.nlm.nih.gov/pubmed/17513923,

http://www.ncbi.nlm.nih.gov/pubmed/16055568.

Really need a hysterectomy?  Make it a happy one, keep your ovaries.

I have the privelege of contributing my literature reviews to the Journal of Sexual Medicine (JSM). Below you’ll find my JSM synopsis of the SOPHIA trial:

Predictors of Hysterectomy Use and Satisfaction. Kuppermann M, Learman LA, Schembri M, Gregorich SE, Jackson R, Jacoby A, Lewis , Washington AE. Obstet Gynecol 2010 Mar, 115(3):543-551. This prospective observational Study of Pelvic Problems, Hysterectomy, an Intervention Alternatives (SOPHIA) monitored 1420 women over a 10 year period, to describe the natural history of the choice to choose or forego hysterectomy in premenopausal participants with benign clinical conditions for which hysterectomy was one management alternative. Baseline evaluation included pelvic symptom profile, quality of life scoring, sexual function and hysterectomy and uterus-related attitudes, in addition to use of Western and alternative medicine therapies. Hysterectomy and uterus related attitude evaluation included “benefits of not having uterus” (lack of menstruation, uselessness of uterus once childbearing complete, no more birth control concerns), “value of uterus (sexual function and feeling complete as a woman) and “hysterectomy concerns” (feeling older, violated, and sad about loss of fertility resulting from hysterectomy). Participants were English, Spanish or Chinese speaking women ages 31-54 at enrollment in trial. Over the 10 year period, 207 (14.6%) underwent hysterectomy, some of whom received up to 8 years of follow-up before end of trial. Approximately 64% of these hysterectomy women were very satisfied, with ~22% somewhat satisfied, and the remaining 15-16% neither satisfied or unsatisfied, ~7% of whom were dissatisfied to varying degrees. Women satisfied with hysterectomy had higher QOL and / or sexual function impact from the condition for which hysterectomy was performed, in addition to higher scores on the “benefits of not having a uterus” and lower scores on the “value of having a uterus” and “hysterectomy concerns” questions. The authors describe a greater likelihood to undergo and be satisfied with the outcome hysterectomy in women reporting greater pelvic problem impact on sexual function and pelvic problems overall, underscoring “the importance of determining the extent to which symptoms interfere with QOL and sexual function when counseling patients about hysterectomy and its outcomes”. The majority of women who underwent alternative therapies such as endometrial ablation and uterine artery embolization, did not go on to hysterectomy. The data clearly demonstrate the conclusion that “women’s attitudes toward their uterus and hysterectomy play a primary role in the decision to undergo and personal satisfaction with the outcome of hysterectomy” for benign conditions. Level of Evidence: IIa